REGULATION BY CA2+-DSRNA OF THE PROLIFERATION AND TERMINAL DIFFERENTIATION OF HUMAN FIBROBLASTS AND HELA-CELLS

被引：0
|
作者：
ZAKHARYAN, RA
机构：
来源：
BIOCHEMISTRY-MOSCOW | 1991年 / 56卷 / 11期
关键词：
FIBROBLASTS; HELA; CA-DSRNA; DIFFERENTIATION; PROLIFERATION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ca2+-Complexes of dsRNA, poly(dA), poly(dT), and low-molecular-weight yeast RNA have a rather pronounced mitogenic effect on human fibroblasts at early stages of fibroblast reproduction in culture. In later stages of cell culture, Ca2+-dsRNA stimulated terminal differentiation, inducing the synthesis of a group of proteins characteristic of the postmitotic population of human fibroblasts that had undergone terminal differentiation. Ca2+-dsRNA had a stimulating effect on the transcription of c-fos and c-jun genes in fibroblasts and HeLa-S-3.
引用
收藏
页码：1384 / 1390
页数：7
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