EFFECT OF CANINE SURFACTANT PROTEIN (SP-A) ON THE RESPIRATORY BURST OF PHAGOCYTIC-CELLS

被引：42

作者：

WEBER, H ^{[1
]}

HEILMANN, P ^{[1
]}

MEYER, B ^{[1
]}

MAIER, KL ^{[1
]}

机构：

[1] GESELL STRAHLEN & UMWELTFORSCH MBH,PROJEKT INHALAT,INGOLSTADTER LANDSTR 1,W-8042 NEUHERBERG,GERMANY

来源：

FEBS LETTERS | 1990年 / 270卷 / 1-2期

关键词：

Alveolar macrophage; Beagle dog; Chemiluminescence; Neutrophil; Respiratory burst; Surfactant; Surfactant associated protein A;

D O I：

10.1016/0014-5793(90)81241-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells obtained from bronchoalveolar lavage, or neutrophils of peripheral blood of dog, were incubated with the canine surfactant-associated protein A (SP-A). A significant decrease of the production of Superoxide anion was observed after subsequent stimulation with phorbol-12-myristate-13-acetate (PMA) as measured by the lucigenin-dependent chemiluminesence (CL). Several other proteins used for control experiments did not decrease lucigenin-dependent CL, indicating a specific effect of SP-A on phagocytes. Treatment of SP-A with collagenase prior to incubation with neutrophils destroyed the depleting effect on oxygen radical production of PMA-stimulated cells. We propose that SP-A acts as a regulatory factor of the respitatory burst of alveolar macrophages and neutrophils in the lungs. The inhibitory effect of SP-A is down-regulated by collagenase released from stimulated alveolar macrophages. © 1990.

引用

页码：90 / 94

页数：5

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