SYNTHESIS OF 5,8-DICHLORO-3-METHYL-4H-1,4-BENZOTHIAZINES AND THEIR CONVERSION INTO SULFONES

被引：11
|
作者：
GUPTA, A [1 ]
SARASWAT, V [1 ]
GUPTA, SK [1 ]
GUPTA, R [1 ]
MUKHERJI, SK [1 ]
GUPTA, RR [1 ]
机构：
[1] UNIV RAJASTHAN,DEPT CHEM,JAIPUR 302004,RAJASTHAN,INDIA
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1993年 / 85卷 / 1-4期
关键词：
4H-1,4-BENZOTHIAZINES; 1,4-BENZOTHIAZINE SULFONES; 3,6-DICHLORO-2-AMINOBENZENETHIOL; BETA-DIKETONES; BETA-KETOESTERS;
D O I：
10.1080/10426509308038187
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The present work consists of the one pot synthesis of 5,8-dichloro-3-methyl-4H-1,4-benzothiazines by the condensation and oxidative cyclization of 2-amino-3,6-dichlorobenzenethiol with beta-diketones/beta-ketoesters in dimethyl sulfoxide and oxidation behaviour of 4H-1,4-benzothiazines by 30% hydrogen peroxide in glacial acetic acid to 1,4-benzothiazine sulfones. The structure of all the newly synthesized compounds has been confirmed by elemental analysis and spectral studies.
引用
收藏
页码：101 / 106
页数：6
相关论文
共 50 条
  • [41] REACTIONS OF ENAMINO KETONES .2. SYNTHESIS OF H-4-1,4-BENZOTHIAZINES
    MIYANO, S
    ABE, N
    SUMOTO, K
    TERAMOTO, K
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (10): : 1146 - 1149
  • [42] Synthesis and Spectral studies of Nitrosourea derivatives of 3-Methyl-5/7-Substituted-2-(3,4-dichloro) benzoyl-4H-1,4-Benzothiazines as Bifunctional Anticancer Agents.
    Gupta, Rajni
    Gupta, Vandana
    HETEROCYCLIC COMMUNICATIONS, 2010, 16 (01) : 65 - 71
  • [43] REGIOSELECTIVE ONE-POT SYNTHESIS OF 5-CHLORO-3-METHYL-8-TRIFLUOROMETHYL-4H-1, 4-BENZOTHIAZINES
    Ankodia, Vandana
    Sharma, Praveen Kumar
    Sharma, Kailash
    Kumar, M.
    Gupta, Archana
    HETEROCYCLIC COMMUNICATIONS, 2009, 15 (02) : 127 - 133
  • [44] METALATION OF 4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINES AND REACTIONS WITH ELECTROPHILES
    BABUDRI, F
    DINUNNO, L
    FLORIO, S
    SYNTHESIS-STUTTGART, 1982, (06): : 488 - 490
  • [45] A convenient synthesis of 5/7-chloro-4H-1, 4-benzothiazines
    Kumar, G
    Gupta, V
    Gautam, DC
    Gupta, RR
    HETEROCYCLIC COMMUNICATIONS, 2002, 8 (04) : 381 - 384
  • [46] A SINGLE STEP AND CONVENIENT SYNTHESIS OF SUBSTITUTED 3-METHYL-2-(2,4-DIMETHOXYBENZOYL)-4H-1,4-BENZOTHIAZINES
    GUPTA, RR
    JAIN, SK
    GUPTA, V
    RATHORE, RK
    PHARMAZIE, 1989, 44 (08): : 572 - 572
  • [47] SINGLE STEP SYNTHESIS OF FLUORINATED 4H-1,4-BENZOTHIAZINES AS POSSIBLE ANTICANCER AGENTS
    GUPTA, V
    GUPTA, RR
    JOURNAL FUR PRAKTISCHE CHEMIE, 1991, 333 (01): : 153 - 156
  • [48] SYNTHESIS OF 4H-1,4-BENZOTHIAZINES VIA LITHIATION-ALPHA TO SULFUR OF 2-ACYLAMINOPHENYL ALKYL SULFIDES, SULFOXIDES, AND SULFONES
    BABUDRI, F
    FLORIO, S
    VITRANI, AM
    DINUNNO, L
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (08): : 1899 - 1903
  • [49] A STUDY OF SYNTHESIS AND SOME REACTIONS OF 3-PHENYL-1,4-BENZOTHIAZINES
    WILHELM, M
    SCHMIDT, P
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1969, 6 (05) : 635 - &
  • [50] SUBSTITUTED 3-(DIALKYLAMINO)-2H-1,4-BENZOTHIAZINES
    BALBI, A
    FERRECCIO, R
    DIBRACCIO, M
    MAZZEI, M
    ROMA, G
    FARMACO-EDIZIONE SCIENTIFICA, 1987, 42 (12): : 955 - 961
12345