CHARACTERIZATION OF URSOLIC ACID AS A LIPOXYGENASE AND CYCLOOXYGENASE INHIBITOR USING MACROPHAGES, PLATELETS AND DIFFERENTIATED HL-60 LEUKEMIC-CELLS

被引：105
|
作者：
NAJID, A
SIMON, A
COOK, J
CHABLERABINOVITCH, H
DELAGE, C
CHULIA, AJ
RIGAUD, M
机构：
[1] UNIV LIMOGES,FAC PHARM,PHARMACOGNOSIE LAB,F-87025 LIMOGES,FRANCE
[2] UNIV LIMOGES,FAC PHARM,CHIM PHYS LAB,F-87025 LIMOGES,FRANCE
来源：
FEBS LETTERS | 1992年 / 299卷 / 03期
关键词：
LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE; URSOLIC ACID; CALLUNA-VULGARIS;
D O I：
10.1016/0014-5793(92)80117-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1-mu-M, blocks arachidonate metabolism.
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页码：213 / 217
页数：5
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