PIRKLE-CONCEPT CHIRAL STATIONARY PHASES FOR THE HPLC SEPARATION OF PHARMACEUTICAL RACEMATES

被引：28
|
作者：
CLEVELAND, T
机构：
[1] Phenomenex, Inc., Torrance, California 90501
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY | 1995年 / 18卷 / 04期
关键词：
D O I：
10.1080/10826079508009263
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The enantioselectivity of various Pirkle-concept chiral stationary phases (CSPs) for the direct HPLC separation of chiral drugs is explored and discussed. Seven different CSPs are surveyed for their utility to separate enantiomeric pairs belonging to the following major pharmaceutical classes: cardiovascular medicines (antihypertensives, antiarrhythmics, antianginals, diuretics), adrenergic drugs (vasopressors), antiinflammatory and analgesic compounds, topical anesthetics, antihistaminics, and antimalarial therapeutics.
引用
收藏
页码：649 / 671
页数：23
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