IN-VITRO IN-VIVO CORRELATION STUDIES ON A NOVEL CONTROLLED-RELEASE THEOPHYLLINE DELIVERY SYSTEM AND ON THEO-DUR TABLETS

被引：19
|
作者：
MUNDAY, DL [1 ]
FASSIHI, AR [1 ]
机构：
[1] TEMPLE UNIV,SCH PHARM,PHILADELPHIA,PA 19122
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 118卷 / 02期
关键词：
CONTROLLED RELEASE; THEOPHYLLINE; IN VITRO IN VIVO CORRELATION; BIOAVAILABILITY;
D O I：
10.1016/0378-5173(94)00391-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A good correlation should be obtained between data derived from in vitro dissolution and bioavailability studies on drug delivery systems if bioavailability parameters are to be reliably predicted from the in vitro dissolution variables. This study compares the in vivo absorption with the in vitro dissolution profiles into various dissolution media of a novel controlled release theophylline capsule (Mintab) containing mini-matrices, and also those of Theo-Dur 300 mg tablets. Mintab displayed significant pharmacokinetic advantages over Theo-Dur. However, Theo-Dur demonstrated good in vitro-in vivo correlation, whereas Mintab showed poor correlation.
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页码：251 / 255
页数：5
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