CALIBRATION SOLUTIONS FOR THE SIMULTANEOUS POTENTIOMETRIC MEASUREMENT OF SODIUM, POTASSIUM AND CALCIUM IN BLOOD-PLASMA - EXAMINATION OF THE ELECTROCHEMICAL FACTORS AFFECTING PRECISION AND ACCURACY IN DIRECT POTENTIOMETRIC CLINICAL ANALYZERS

被引：5

作者：

COVINGTON, AK ^{[1
]}

KATAKY, R ^{[1
]}

机构：

[1] UNIV DURHAM,DEPT CHEM,SCI LABS,DURHAM DH1 3LE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS | 1993年 / 89卷 / 02期

关键词：

D O I：

10.1039/ft9938900369

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of well defined calibration solutions is proposed to eliminate some of the discrepancies in the measurement of sodium, potassium and calcium in blood plasma by ion-selective electrode potentiometry. The calibration matrix has been chosen to resemble the electrolyte composition of blood plasma in terms of ionic composition and ionic strength. This reduces liquid-junction and activity coefficient bias. A flow-through test rig was constructed from sodium, potassium and calcium ion-selective electrode modules from commercial instruments and a single ceramic plug KCl reference electrode. These modules were calibrated with the proposed solutions and used in blood plasma. Preliminary experiments were performed to evaluate residual liquid-junction potentials and the effects of heparin and carbon dioxide.

引用

页码：369 / 376

页数：8