Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen

被引：10
|
作者：
Mortazavi, Y. [1 ]
Ghoreishi, S. M. [2 ]
机构：
[1] Babol Univ Med Sci, Pramed Fac, Anesthesiol & Operat Dept, Babol Sar, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Dept Radiopharm, Tehran, Iran
来源：
JOURNAL OF NANOSTRUCTURES | 2016年 / 6卷 / 01期
关键词：
APTES; Drug delivery; Ibuprofen; Mesoporous silica;
D O I：
10.7508/jns.2016.01.014
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by Fourier transform infrared spectroscopy, Scanning electron microscopy, X-ray diffraction, and ultraviolet-visible. the Fourier transform infrared spectroscopy result demonstrate that organic group were successfully functionalized onto mesoporous silica nanoparticles. Then, we investigate of the adsorption and release of ibuprofen as a drug delivery system in simulated body fluid. The result demonstrates that high adsorption capacity for drug with functionalized sample and slower drug release rate was achieved.
引用
收藏
页码：86 / 89
页数：4
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