A HYPOTHESIS FOR CHEMICAL CARCINOGEN-INDUCED CHROMATIN CONDENSATION

被引：5
|
作者：
YU, FL
机构：
[1] Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, Rockford, IL 61107
来源：
CARCINOGENESIS | 1993年 / 14卷 / 09期
关键词：
D O I：
10.1093/carcin/14.9.1969
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A hypothesis for chemical carcinogen induced condensation of nuclear and nucleolar chromatin is proposed. Chromatin condensation is believed to be a result of cascade effects initiated by the inhibition of messenger RNA synthesis after exposure to chemical carcinogen in vivo. Inhibition of messenger RNA synthesis leads to the loss of protein production, which in turn causes the dephosphorylation of histone H1 and triggers the condensation of chromatin in vivo.
引用
收藏
页码：1969 / 1970
页数：2
相关论文
共 50 条
  • [1] CHEMICAL SPECIFICITY OF CARCINOGEN-INDUCED TOLERANCE TO HOMOTRANSPLANTATION
    FOX, HW
    BOCK, FG
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1967, 38 (05) : 789 - &
  • [2] CHEMICAL CARCINOGEN-INDUCED NEOPLASTIC TRANSFORMATION IN-VITRO
    EVANS, CH
    DIPAOLO, JA
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1973, 8 (05): : 431 - &
  • [3] CYTOFLUOROMETRIC QUANTIFICATION OF THE CHEMICAL CARCINOGEN-INDUCED DNA DAMAGE
    HOSOKAWA, Y
    URATA, Y
    HATTORI, T
    FUKUDA, M
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1982, 30 (06) : 591 - 591
  • [4] CHEMICAL CARCINOGEN-INDUCED ALTERATIONS IN POTENTIALS OF CULTURED ANIMAL CELLS
    ALFRED, LJ
    NATURE, 1967, 214 (5089) : 732 - &
  • [5] INHIBITION OF CHEMICAL CARCINOGEN-INDUCED PULMONARY NEOPLASIA BY BUTYLATED HYDROXYANISOLE
    WATTENBERG, LW
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 50 (06): : 1541 - 1544
  • [6] CARCINOGEN-INDUCED TOLERANCE TO HOMOTRANSPLANTATION
    RUBIN, BA
    PROGRESS IN EXPERIMENTAL TUMOR RESEARCH, 1964, 5 : 217 - &
  • [7] A scientometric study of chemical carcinogen-induced experimental oral carcinogenesis with emphasis on
    Zhou, Ziyuan
    Han, Xinyi
    Shen, Shukun
    Sun, Kai
    Liu, Wei
    JOURNAL OF DENTAL SCIENCES, 2024, 19 (01) : 614 - 619
  • [8] Tobacco carcinogen-induced transformation of HBECs is associated with chromatin-mediated reprogramming of the epigenome
    Tellez, Carmen S.
    Juri, Daniel E.
    Van Neste, Leander
    Hart, Christopher
    Liu, Yushi
    Do, Kieu
    Picchi, Maria A.
    Belinsky, Steven A.
    CANCER RESEARCH, 2011, 71
  • [9] STUDIES ON CHEMICAL CARCINOGEN-INDUCED IMMUNE SUPPRESSION USING INVITRO MODELS
    DEAN, JH
    HOUSE, RV
    LAUER, LD
    WARD, EC
    MURRAY, MJ
    INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1985, 7 (04): : 624 - 624
  • [10] SERIAL TRANSPLANTATION OF CHEMICAL CARCINOGEN-INDUCED MOUSE MAMMARY DUCTAL DYSPLASIAS
    MEDINA, D
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1979, 62 (02) : 397 - 405
12345