METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF CAPECITABINE BY RP-HPLC METHOD

被引：0
|
作者：
Fathima, Azka [1 ]
Gazi, Shaik [1 ]
机构：
[1] Deccan Sch Pharm, Dept Pharmaceut Anal &QA, Hyderabad 500001, India
来源：
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 5卷 / 08期
关键词：
Capecitabine; RP-HPLC; validation;
D O I：
10.5281/zenodo.1402154
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Capecitabine, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6x150mm, 5 mu m) column using a mixture of Acetonitrile: Water (50:50v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245 nm. The retention time of the Capecitabine was 2.4 +/- 0.02min. The method produce linear responses in the concentration range of 15-75mg/ml of Capecitabine. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
引用
收藏
页码：7808 / 7814
页数：7
相关论文
共 50 条
  • [1] METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE IN TABLETS BY RP-HPLC METHOD
    Rao, M. Prasada
    Leelavathi, K.
    Chandreshta, N.
    Sowjanya, V.
    Sireesha, I.
    Rajani, I.
    Premi, V. V. Naga
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 3 (05): : 492 - 507
  • [2] RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF AZELNIDIPINE
    Gore, Megha G.
    Dabhade, Pratap S.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (12): : 5111 - 5114
  • [3] RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE EXTENDED RELEASE TABLET DOSAGE FORM
    Sreevatsav, A. Santosh Kumar
    Harishbabu, A. K.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2013, 4 (11): : 4477 - 4487
  • [4] BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LENVATINIB BY RP-HPLC METHOD
    Veni, G. Krishna
    Ajitha, A.
    Abbulu, K.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (07): : 3313 - 3319
  • [5] Method development and validation of asenapine in bulk by RP-HPLC method
    Aarelly, K., 1600, Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India (04):
  • [6] Development and validation of RP-HPLC method for the determination of Cefazolin
    Lalitha, N.
    Pawar, Varun
    Puranik, S. B.
    Pai, P. N. Sanjay
    Rao, G. K.
    ORIENTAL JOURNAL OF CHEMISTRY, 2008, 24 (01) : 153 - 156
  • [7] METHOD DEVELOPMENT AND VALIDATION OF DONEPEZIL HYDROCHLORIDE BY RP-HPLC
    Dusia, Sharmila
    Ramanamma, L.
    Prasad, D. S. V. S.
    INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 5 (05): : 4228 - 4251
  • [8] Development and validation of the RP-HPLC method for quantification of tavaborole
    Prajapati, Shiv Kumar
    Jain, Ankit
    Bajpai, Meenakshi
    ANALYTICAL METHODS, 2024, 16 (30) : 5280 - 5287
  • [9] Development and Validation of a RP-HPLC Method for Simvastatin Capsules
    Marques-Marinho, Flavia Dias
    Freitas, Bruna Diniz
    da Costa Zanon, Jose Carlos
    Reis, Ilka Afonso
    Lima, Angelica Alves
    Vianna-Soares, Cristina Duarte
    CURRENT PHARMACEUTICAL ANALYSIS, 2013, 9 (01) : 2 - 12
  • [10] Analytical method development and validation of Artemether by RP-HPLC
    Sumithra, M.
    Surya, S.
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2024, 13 (01): : 709 - 714
12345