SYNTHESIS OF NOVEL FLUORINATED BISPHOSPHONATES AND BISPHOSPHONIC ACIDS

被引：26

作者：

NAIR, HK ^{[1
]}

GUNERATNE, RD ^{[1
]}

MODAK, AS ^{[1
]}

BURTON, DJ ^{[1
]}

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 09期

关键词：

D O I：

10.1021/jo00088a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel fluorinated bisphosphonates with two, three, four, and six difluoromethylene groups (1a, 1b, 8, 12, and 15) (44-78%) by different approaches is described. The bisphosphonates were converted to the corresponding trimethylsilyl esters which on treatment with deionized water afforded the respective bisphosphonic acids (6, 10, and 14) in good yields.

引用

页码：2393 / 2398

页数：6

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