Effect of methionine synthase A2756G and methionine synthase reductase A66G gene polymorphisms in male infertility

被引：3
|
作者：
Kucukaslan, Ali Sahin [1 ]
Altintas, Rasit [2 ]
Cetintas, Vildan Bozok [1 ]
Tetik, Asli [1 ]
Ulukus, Murat [3 ]
Semerci, Bulent [2 ]
Eroglu, Zuhal [1 ]
机构：
[1] Ege Univ, Tip Fak, Tibbi Biyol Anabilim Dali, Izmir, Turkey
[2] Ege Univ, Tip Fak, Urol Anabilim Dali, Izmir, Turkey
[3] Ege Univ, Tip Fak, Kadin Hastaliklari & Dogum Anabilim Dali, Izmir, Turkey
来源：
TURKISH JOURNAL OF UROLOGY | 2011年 / 37卷 / 01期
关键词：
Azoospermia; folate metabolism; male infertility; methionine synthase reductase; oligozoospermia; polymorphism;
D O I：
10.5152/tud.2011.008
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: In this study, we investigated whether methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms were related with infertility. Materials and methods: Blood samples of 117 infertile (66 azoospermia, 51 oligozoospermia) cases and 70 healthy men were collected and genotyped for MTR A2756G and MTRR A66G polymorphisms. Results: In control and study groups MTR A2756G genotypes were 64% AA, 34% AG, 1% GG and 54% AA, 39% AG, 7% GG, respectively, and the frequency of the G allele in the study group was increased compared to control group (p<0.05). MTRR A66G genotypes were 9% AA, 79% AG, 13% GG in control group and 4% AA, 73% AG, 23% GG in control group without statistically significant difference (p>0.05). Conclusion: MTR A2756G gene polymorphism may have an important effect on the evolution of male infertility. Finding of increased G allele frequency of study group will lead to further and larger sample-size studies.
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收藏
页码：38 / 42
页数：5
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