Synthesis of Novel Fused Pyrimidines and Imidazoles as Potential Analgesics from 2-Amino-4-substituted-s-triazino[1,2-a]-benzimidazoles

被引：0

作者：

El-Feky, Said A. ^{[1
,2
]}

Thabet, Hamdy Kh. ^{[3
,4
]}

Mudawi-, Mahmoud M. E. ^{[5
,6
]}

机构：

[1] Northern Border Univ, Fac Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[2] Zagazig Univ, Dept Pharmaceut Organ Chem, Fac Pharm, Zagazig 44511, Egypt

[3] Northern Border Univ, Fac Arts & Sci, Dept Chem, Rafha 91911, Saudi Arabia

[4] Al Azhar Univ, Fac Sci, Dept Chem, Cairo 11284, Egypt

[5] Northern Border Univ, Fac Pharm, Dept Pharmacol & Toxicol, Rafha 91911, Saudi Arabia

[6] Islamic Univ, Fac Pharm, Dept Pharmacol, Omdurman, Sudan

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2015年 / 31卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of novel fused pyrimidines and imidazole derivatives from 2-amino-s-triazino[1,2a] benzimidazoles 2a-e and 3a-c was successfully carried out by a ring annelation reaction in a very good yield. Compound 3c was screened for analgesic activity against acetic acid irritation and has shown protection equal to the reference drug (diclofenac sodium). The acute toxicity study revealed that compound 3c is safe up to 300 mg/kg and there is no sign and symptoms of toxicity and mortality for 72 hours.

引用

页码：709 / 718

页数：10

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