MICROBIAL CONVERSION OF AVERMECTINS BY SACCHAROPOLYSPORA-ERYTHRAEA - GLYCOSYLATION AT C-4' AND C-4''

被引：9
|
作者：
SCHULMAN, M
DOHERTY, P
ARISON, B
机构：
[1] Merck Research Laboratories, Rahway, NJ 07065
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 09期
关键词：
D O I：
10.1128/AAC.37.9.1737
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Avermectins and ivermectins are glycosylated at C-4'' and C-4' by both growing and resting cells of Saccharopolyspora erythraea. The reaction is catalyzed by a glycosyltransferase which is constitutive. The enzyme uses UDP-glucose as the glycosyl donor and avermectin or ivermectin mono- and disaccharides as acceptors. Avermectin and ivermectin aglycones and erythromycin A are not substrates for the enzyme.
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页码：1737 / 1741
页数：5
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