A LINEAGE-SPECIFIC T(1,14)(Q21,Q32) AS AN EARLY EVENT IN DEVELOPMENT OF B-CELL CLONAL EXPANSION

被引：6
|
作者：
PINKERTON, PH
REIS, MD
DECOTEAU, J
SRIGLEY, JR
DUBE, ID
LONDON, B
机构：
[1] UNIV TORONTO,SUNNYBROOK HLTH SCI CTR,DEPT PATHOL,TORONTO M5S 1A1,ONTARIO,CANADA
[2] UNIV TORONTO,DEPT PATHOL,CANC CYTOGENET PROGRAM,TORONTO M5S 1A1,ONTARIO,CANADA
来源：
CANCER GENETICS AND CYTOGENETICS | 1992年 / 64卷 / 02期
关键词：
D O I：
10.1016/0165-4608(92)90349-D
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a patient in whom a cell line of 47,XY,+X,t(1;14)(q21;q32) constitution was found in a lymph node excised from the neck. Histologic examination and immunophenotyping both in situ and by flow cytometry failed to confirm a diagnosis of B-cell lymphoma, but Southern analysis indicated the presence of B-cell clonal expansion. These observations support the concept that primary chromosomal abnormalities occur in clonal expansions in the very earliest stages of tumorigenesis.
引用
收藏
页码：166 / 169
页数：4
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