IMMUNOLOGY OF CELIAC-DISEASE - TISSUE AND SPECIES SPECIFICITY OF ENDOMYSIAL AND RETICULIN ANTIBODIES

被引:0
|
作者
VALESKI, JE
KUMAR, V
BEUTNER, EH
LERNER, A
CHORZELSKI, TP
机构
[1] SUNY BUFFALO,ERNEST WITEBSKY CTR IMMUNOL,DEPT MICROBIOL,225 SHERMAN HALL,BUFFALO,NY 14214
[2] LADY DAVIES CARMEL HOSP,DEPT PEDIAT,IL-34362 HAIFA,ISRAEL
[3] MED ACAD WARSAW,DEPT DERMATOL,PL-02032 WARSAW,POLAND
来源
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 93卷 / 01期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Patients with celiac disease and dermatitis herpetiformis have circulating antibodies to reticulin and endomysium, the 'extracellular matrix' components as defined by their detection on rodent and primate tissues, respectively. Because both types of antibodies occur in both forms of gluten-sensitive enteropathy, studies were conducted to determine if the two types of antibodies can be distinguished by species and organ specificity. The results of these studies indicate that distinct endomysium-specific and reticulin-specific antibodies can be found and that these differ in their species specificity; i.e., endomysium antigen occurs in primate and not in rodent tissues while the reticulin antigen occurs in rodent and not in primate tissues. However, the activity of both endomysium and reticulin antibodies demonstrates similar tissue distribution, in that both react to antigens associated with gastrointestinal smooth muscles, peritubular and periglomerular areas of the kidney, and sinusoidal and periportal areas of the liver. Also, both antigens seem to be present in sheep and goat tissue. These studies indicate that the antigens reactive with endomysial antibodies are distinct from those reactive with reticulin antibodies.
引用
收藏
页码:1 / 7
页数:7
相关论文
共 50 条
  • [1] SEROLOGICAL STUDIES ON THE SPECIFICITY AND SENSITIVITY OF ENDOMYSIAL AND RETICULIN ANTIBODIES IN CELIAC-DISEASE
    KUMAR, V
    LERNER, A
    CHORZELSKI, TP
    BEUTNER, EH
    LEBENTHAL, E
    GASTROENTEROLOGY, 1987, 92 (05) : 1484 - 1484
  • [2] RETICULIN ANTIBODIES IN PATIENTS WITH CELIAC-DISEASE AND THEIR RELATIVES
    STEVENS, FM
    LLOYD, R
    EGANMITCHELL, B
    MYLOTTE, MJ
    FOTTRELL, PF
    WRIGHT, R
    MCNICHOLL, B
    MCCARTHY, CF
    GUT, 1975, 16 (08) : 598 - 602
  • [3] GLIADIN AND RETICULIN ANTIBODIES IN CHILDHOOD CELIAC-DISEASE
    UNSWORTH, DJ
    WALKERSMITH, JA
    HOLBOROW, EJ
    LANCET, 1983, 1 (8329): : 874 - 875
  • [4] DISEASE SPECIFICITY AND DYNAMICS OF CHANGES IN IGA CLASS ANTI-ENDOMYSIAL ANTIBODIES IN CELIAC-DISEASE
    KAPUSCINSKA, A
    ZALEWSKI, T
    CHORZELSKI, TP
    SULEJ, J
    BEUTNER, EH
    KUMAR, V
    ROSSI, T
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1987, 6 (04): : 529 - 534
  • [5] RETICULIN ANTIBODIES IN CHILDREN SUFFERING FROM THE CELIAC-DISEASE
    HENKER, J
    ZUGEHOR, M
    MORENZ, J
    DEUTSCHE GESUNDHEITSWESEN-ZEITSCHRIFT FUR KLINISCHE MEDIZIN, 1979, 34 (02): : 83 - 86
  • [6] IGA CLASS RETICULIN ANTIBODIES IN RELATIVES OF PATIENTS WITH CELIAC-DISEASE
    MALLAS, EG
    WILLIAMSON, N
    COOPER, BT
    COOKE, WT
    GUT, 1977, 18 (08) : 647 - 650
  • [7] COMPARISON OF RETICULIN (ARA) AND ENDOMYSIUM (EMA) ANTIBODIES IN CELIAC-DISEASE
    MAKI, M
    HALLSTROM, O
    POLANCO, I
    VISAKORPI, JK
    PEDIATRIC RESEARCH, 1988, 24 (03) : 406 - 406
  • [8] IGA ANTIBODIES TO ENDOMYSIUM, GLIADIN, AND RETICULIN IN SILENT CELIAC-DISEASE
    VOLTA, U
    BIANCHI, FB
    LANCET, 1992, 339 (8787): : 242 - 242
  • [9] SERUM ANTIBODIES AGAINST GLIADIN AND RETICULIN IN A FAMILY STUDY OF CELIAC-DISEASE
    STERN, M
    BENDER, SW
    GRUTTNER, R
    POSSELT, HG
    STROBEL, S
    EUROPEAN JOURNAL OF PEDIATRICS, 1980, 135 (01) : 31 - 36
  • [10] IGG ENDOMYSIAL ANTIBODIES IN IGA-DEFICIENT PATIENT WITH CELIAC-DISEASE
    BEUTNER, EH
    KUMAR, V
    CHORZELSKI, TP
    SZAFLARSKACZERWIONKA, M
    LANCET, 1989, 1 (8649): : 1261 - 1262