ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .1. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS FROM STREPTOMYCES-VIOLACEUS A262

被引：24

作者：

JOHDO, O ^{[1
]}

ISHIKURA, T ^{[1
]}

YOSHIMOTO, A ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 10期

关键词：

D O I：

10.7164/antibiotics.44.1110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five mutant (or variant) strains producing new anthracycline antibiotics were derived from Streptomyces violaceus A262 by mutagenesis treatment. Strain SE1-625 showed a limited production of three known beta-rhodomycinone diglycosides while the parent strain produced numerous unidentified beta-rhodomycinone glycosides. Strain SU2-730 was an antibiotic-blocked mutant which produced only epsilon-rhodomycinone glycosides (named epelmycins). Strains SC-7 and SE2-2385 were variants which produced alpha-citromycinone glycosides (named yellamycins) and beta-isorhodomycinone glycosides (named obelmycins), respectively. Strain SE2-2385-Al produced alpha-2-rhodomycinone glycosides. (named alldimycins). Glycosidation-less mutants which accumulated only aglycone were also obtained. Isolation of these mutants or variants and preliminary identification of their anthracycline products are described.

引用

页码：1110 / 1120

页数：11

共 16 条

[1] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .2. NEW ANTHRACYCLINE EPELMYCINS PRODUCED BY A BLOCKED MUTANT STRAIN SU2-730
JOHDO, O
WATANABE, Y
ISHIKURA, T
YOSHIMOTO, A
NAGANAWA, H
SAWA, T
TAKEUCHI, T
JOURNAL OF ANTIBIOTICS, 1991, 44 (10): : 1121 - 1129
[2] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .4. NEW ANTHRACYCLINE YELLAMYCINS PRODUCED BY A VARIANT STRAIN SC-7
JOHDO, O
TONE, H
OKAMOTO, R
YOSHIMOTO, A
NAGANAWA, H
SAWA, T
TAKEUCHI, T
JOURNAL OF ANTIBIOTICS, 1991, 44 (10): : 1155 - 1159
[3] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .5. NEW ANTHRACYCLINE ALLDIMYCIN-A - A MINOR COMPONENT ISOLATED FROM OBELMYCIN BEER
JOHDO, O
TONE, H
OKAMOTO, R
YOSHIMOTO, A
NAGANAWA, H
SAWA, T
TAKEUCHI, T
JOURNAL OF ANTIBIOTICS, 1991, 44 (10): : 1160 - 1164
[4] ANTHRACYCLINE METABOLITES FROM STREPTOMYCES-VIOLACEUS A262 .3. NEW ANTHRACYCLINE OBELMYCINS PRODUCED BY A VARIANT STRAIN SE2-2385
JOHDO, O
WATANABE, Y
ISHIKURA, T
YOSHIMOTO, A
NAGANAWA, H
SAWA, T
TAKEUCHI, T
JOURNAL OF ANTIBIOTICS, 1991, 44 (10): : 1130 - 1140
[5] NEW RHODOMYCIN ANALOGS, SS-288A AND SS-288B, PRODUCED BY A STREPTOMYCES-VIOLACEUS A262 MUTANT
SAITO, S
KATSUDA, Y
JOHDO, O
YOSHIMOTO, A
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1995, 59 (01) : 135 - 137
[6] SECONDARY METABOLITES BY CHEMICAL-SCREENING .10. GLYCERINOPYRIN, A NOVEL METABOLITE FROM STREPTOMYCES-VIOLACEUS
SCHONEWOLF, M
GRABLEY, S
HUTTER, K
MACHINEK, R
WINK, J
ZEECK, A
ROHR, J
LIEBIGS ANNALEN DER CHEMIE, 1991, (01): : 77 - 80
[7] ANTHRACYCLINE METABOLITES FROM BAUMYCIN-PRODUCING STREPTOMYCES SP D788 .1. ISOLATION OF ANTIBIOTIC-BLOCKED MUTANTS AND THEIR CHARACTERIZATION
YOSHIMOTO, A
JOHDO, O
FUJII, S
KUBO, K
NISHIDA, H
OKAMOTO, R
TAKEUCHI, T
JOURNAL OF ANTIBIOTICS, 1992, 45 (08): : 1255 - 1267
[8] NEW ANTHRACYCLINE ANTIBIOTICS PRODUCED BY INTERSPECIFIC RECOMBINANTS OF STREPTOMYCETES .1. SELECTION OF STREPTOMYCES-VIOLACEUS SUBSP IREMYCETICUS, AN IREMYCIN-PRODUCING SUBSPECIES
SCHLEGEL, B
FLECK, WF
ZEITSCHRIFT FUR ALLGEMEINE MIKROBIOLOGIE, 1980, 20 (08): : 527 - 530
[9] SALMYCIN A-D, ANTIBIOTICS FROM STREPTOMYCES-VIOLACEUS, DSM-8286, HAVING A SIDEROPHORE AMINOGLYCOSIDE STRUCTURE
VERTESY, L
ARETZ, W
FEHLHABER, HW
KOGLER, H
HELVETICA CHIMICA ACTA, 1995, 78 (01) : 46 - 60
[10] NEW ANTHRACYCLIN ANTIBIOTICS FROM STREPTOMYCES-VIOLACEUS STRAIN-43664 - ISOLATION AND STRUCTURAL DETERMINATION OF ALPHA-RUBICIN-I AND ALPHA-RUBICIN-II
KOCH, W
IHN, W
TRESSELT, D
FLECK, W
ZEITSCHRIFT FUR CHEMIE, 1983, 23 (07): : 271 - 271

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