NICOTINE REINFORCEMENT IN RATS WITH HISTORIES OF COCAINE SELF-ADMINISTRATION

被引：37
|
作者：
TESSARI, M
VALERIO, E
CHIAMULERA, C
BEARDSLEY, PM
机构：
[1] Glaxo Research Laboratories, Verona, I-37100
来源：
PSYCHOPHARMACOLOGY | 1995年 / 121卷 / 02期
关键词：
NICOTINE; COCAINE; SELF-ADMINISTRATION; REINFORCEMENT; RAT;
D O I：
10.1007/BF02245640
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Few reports have described conditions under which nicotine self-administration occurs in rats. In this study, rats which initially lever pressed for cocaine infusion (0.05 mg/kg) during 1 h experimental sessions continued to obtain similar infusion numbers when nicotine (0.03 mg/kg) was available. When saline was substituted for nicotine, infusions decreased from 11.8 +/- 4.5/h to 5.4 +/- 1.1/h but returned to pre-saline levels when it was re-introduced (12.0 +/- 5.5/h). These results indicate that nicotine can serve as a positive reinforcer for rats under the historical and schedule conditions described.
引用
收藏
页码：282 / 283
页数：2
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