EFFECTS OF TJ-35 (SHIGYAKU-SAN) ON GASTRIC-MUCOSAL INJURY INDUCED BY ISCHEMIA-REPERFUSION AND ITS OXYGEN-DERIVED FREE RADICAL-SCAVENGING ACTIVITIES

被引：0
|
作者：
YOSHIKAWA, T
TAKAHASHI, S
ICHIKAWA, H
TAKANO, H
TASAKI, N
YASUDA, M
NAITO, Y
TANIGAWA, T
KONDO, M
机构：
来源：
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 1991年 / 10卷 / 03期
关键词：
TJ-35 (SHIGYAKU-SAN); GASTRIC MUCOSAL INJURY; ISCHEMIA-REPERFUSION; OXYGEN-DERIVED FREE RADICALS; ESR SPIN TRAPPING METHOD;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
We investigated the effects of TJ-35 (Shigyaku-san) on gastric mucosal injury induced by ischemia-reperfusion in rats; and using the electron spin resonance (ESR) spin trapping method, we also assessed its oxygen-derived free radical-scavenging activities. The increase in mucosal lesions and in thiobarbituric acid-reactive substances (as an index of lipid peroxidation) was significantly inhibited by the oral administration of 500 mg/kg of TJ-35; and in addition, TJ-35 demonstrated superoxide and hydroxyl radical-scavenging activities in vitro. These results suggest the possibility that the effects of TJ-35 on gastric mucosal injury induced by ischemia-reperfusion may be the result of its free radical-scavenging activities.
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页码：189 / 196
页数：8
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