ATP-SENSITIVE K+-CHANNELS IN THE HUMAN ADULT VENTRICULAR CARDIOMYOCYTES MEMBRANE

被引：16
|
作者：
BABENKO, AP
SAMOILOV, VO
KAZANTSEVA, ST
SHEVCHENKO, YL
机构：
[1] RUSSIAN MIL MED ACAD,CARDIOVASC SURG CLIN,ST PETERSBURG,USSR
[2] RUSSIAN MIL MED ACAD,BIOPHYS LIVING CELL LAB,ST PETERSBURG,USSR
来源：
FEBS LETTERS | 1992年 / 313卷 / 02期
关键词：
ATP-SENSITIVE K+-CHANNEL; HUMAN ADULT VENTRICULAR CARDIOMYOCYTE;
D O I：
10.1016/0014-5793(92)81432-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using the patch-clamp method in 27 different inside-out patches it was shown for the first time that they defined the basic parameters of the functioning of single ATP-sensitive K+ channels in the human adult ventricular cardiomyocytes membrane. At [K+]o = 140 mM single channel conductance (over the linear part of the I-V relation) reaches 100 pS. The possibility of the existence of these channels' conductance sublevels as well as the cluster character of their localization in sarcolemma is shown. The channel activity demonstrates an obvious run-down with tau at about a minute. The analysed channels possess one open and two closed states.
引用
收藏
页码：148 / 150
页数：3
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