Anti-fungal resistance in candida isolated from oral and diaper rash candidiasis in neonates

被引:27
|
作者
Mohamadi, Jasem [1 ]
Motaghi, Mahsa [2 ]
Panahi, Jafar [3 ]
Havasian, Mohamad Reza [3 ]
Delpisheh, Ali [4 ]
Azizian, Mitra [2 ]
Pakzad, Iraj [2 ,5 ]
机构
[1] Ilam Univ Med Sci, Fac Med, Dept Pediat, Ilam, Iran
[2] Ilam Univ Med Sci, Fac Med, Dept Microbiol, Ilam, Iran
[3] Ilam Univ Med Sci, Student Res Comm, Ilam, Iran
[4] Ilam Univ Med Sci, Fac Med, Dept Epidemiol, Ilam, Iran
[5] Ilam Univ Med Sci, Clin Microbiol Res Ctr, Ilam, Iran
关键词
Drug resistance; Oral candidiasis; Diaper dermatitis;
D O I
10.6026/97320630010667
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The purpose of the present study is to evaluate the sensitivity of Candida species isolated from oral candidiasis and diaper dermatitis infections in children. The children referring to private and public clinics in Ilam, Iran were exmined for oral candidiasis and diaper dermatitis. In this study, 248 oral candidiasis and diaper dermatitis samples were collected and cultured. Candida species were identified by using standard methods. Resistance and sensitivity to amphotericin B, nystatin, ketoconazole, fluconazole, itraconazole, clotrimazole, and posaconazole were determined using the CLSI M44-A standard disk diffusion method. From the 248 studied samples, 149 were positive for Candida, among which the Candida albicans was the most prevalent (64.4%). The resistance of different Candida species to nystatin, itraconazole, fluconazole, ketoconazole, clotrimazole, voriconazole, and posaconazole were 4, 43, 34.2, 34.9, 21.5, 6, and 6.7%, respectively. No resistance to amphotericin B was observed. Considering rather low resistance to nystatin, this drug is the best choice for oral candidiasis and diaper dermatitis.
引用
收藏
页码:667 / 670
页数:4
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