PROTEIN-TAU VARIANTS PRESENT IN PAIRED HELICAL FILAMENTS (PHFS) OF ALZHEIMER BRAINS

被引：8
|
作者：
GACHE, Y
RICOLFI, F
GUILLEMINOT, J
THEISS, G
NUNEZ, J
机构：
[1] HOP HENRI MONDOR,CNRS,INSERM,U282,F-94010 CRETEIL,FRANCE
[2] BAYER AG,INST BIOCHEM,W-5600 WUPPERTAL 1,GERMANY
来源：
FEBS LETTERS | 1990年 / 272卷 / 1-2期
关键词：
Alzheimer disease; Paired helical filament; Protein TAU;
D O I：
10.1016/0014-5793(90)80450-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyclonal anti-TAU antisera directed against native Tau protein and the NH2-terminal side of the mouse TAU sequence were used to determine the nature of the TAU variants present in Alzheimer brains and in PHFs. These antibodies labelled specifically neuroflbrillary tangles and plaque neuntes in Alzheimer brains. On immunoblots of PHF extracts, two entities of 69 and 130 kDa were identified. These TAU-related species were absent from control brains. Protein immunoblot of total Alzheimer and control supernatants were shown to contain the same 4-5 TAU variants but none of the 69 and 130 TAU-related entities found in PHFs. These data suggest that specific TAU species are present in PHFs. © 1990.
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收藏
页码：65 / 68
页数：4
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