STUDY ON CORRELATION OF CD4 COUNT WITH MALIGNANCY IN HIV

BACKGROUND: Malignancies are increasing in HIV patients and Opportunistic infections are decreasing with the use of ART (Anti-Retroviral Therapy). CD4 count is a simple immunological marker useful in HIV patients to assess the disease severity. The study was aimed to know whether CD4 count has any correlation with the incidence of malignancy in HIV patients. METHODOLOGY: Retrospective study was carried out; Using semi-structured proforma, data was collected from Medical Records Department. 40 HIV subjects diagnosed with malignancy was obtained. Fisher's exact test was used to analyze the data statistically. RESULTS: In our study out of 40 subjects with malignancy 80% had CD4 count <200. Among the patients with AIDS defining malignancy 89% (16 patients) had CD4 count<200. Among patients with Non AIDS defining malignancy, around 73% (16 patients) had CD4 count<200. The association of type of malignancy with CD4 count is statistically not significant (p=0.358) but it has positive correlation. Out of 40 patients 21 were in HIV stage 4. Among the patients with stage 4 HIV, around 86% (18) had CD4 count<200. CONCLUSION: CD4 count has Positive correlation with the Incidence of Malignancy in HIV patients.