AUTOLOGOUS NEUTRALIZING ANTIBODIES PREVAIL IN HIV-2 BUT NOT IN HIV-1 INFECTION

被引:74
|
作者
BJORLING, E
SCARLATTI, G
VONGEGERFELT, A
ALBERT, J
BIBERFELD, G
CHIODI, F
NORRBY, E
FENYO, EM
机构
[1] KAROLINSKA INST, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN
[2] NATL BACTERIOL LAB, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN
[3] NATL BACTERIOL LAB, DEPT IMMUNOL, S-10521 STOCKHOLM, SWEDEN
关键词
D O I
10.1006/viro.1993.1160
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human immunodeficiency virus type 2 (HIV-2) has been reported to be less pathogenic than HIV-1. We have investigated the capacity of sera from nine HIV-2-infected individuals to neutralize their own autologous virus. All nine HIV-2-infected individuals neutralized autologous virus with titers ranging between 20 and 320. In contrast, we have previously reported that most HIV-1-infected individuals lack such antibodies. The difference between HIV-1 and HIV-2 infection was statistically significant (P < 0.0002, Pearson test) and the difference in neutralizing antibody prevalence may explain the faster disease progression in HIV-1-infected individuals than in HIV-2-infected individuals. © 1993 Academic Press, Inc.
引用
收藏
页码:528 / 530
页数:3
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