METALS;
HG2+;
CA2+;
SIGNAL TRANSDUCTION;
NEUROTOXICITY;
D O I:
暂无
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Recent epidemiological and experimental research indicates that toxic and carcinogenic effects of certain trace elements including metals may occur at levels compatible with exposure in the general environment. Despite a large number of studies describing metal cytotoxicity, the molecular mechanisms involved are still poorly understood. However, it now appears clear that several metals can interact with proteins involved in signal transduction, including Ca2+ channels and pumps. The resulting impairment of the ability of cells to respond adequately to the stimulation by hormones and growth factors results in the loss of important cell functions and can ultimately compromise cell survival.
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
Aschner, Michael
V. Skalny, Anatoly
论文数: 0引用数: 0
h-index: 0
机构:
Orenburg State Univ, Inst Bioelementol, Orenburg 460018, Russia
Sechenov Univ, IM Sechenov First Moscow State Med Univ, Ctr Bioelementol & Human Ecol, Moscow 119146, RussiaAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
V. Skalny, Anatoly
Lu, Rongzhu
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h-index: 0
机构:
Jiangsu Univ, Sch Med, Dept Prevent Med & Publ Hlth Lab Sci, Zhenjiang 212013, Jiangsu, Peoples R ChinaAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
Lu, Rongzhu
Martins, Airton C.
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h-index: 0
机构:
Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USAAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
Martins, Airton C.
论文数: 引用数:
h-index:
机构:
Tsatsakis, Aristidis
Miroshnikov, Sergey A.
论文数: 0引用数: 0
h-index: 0
机构:
Orenburg State Univ, Inst Bioelementol, Orenburg 460018, RussiaAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
Miroshnikov, Sergey A.
Santamaria, Abel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Metropolitana Xochimilco, Dept Atenc Salud, Lab Nanotecnol & Nanomed, Mexico City 04960, Mexico
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, MexicoAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
Santamaria, Abel
Tinkov, Alexey A.
论文数: 0引用数: 0
h-index: 0
机构:
Orenburg State Univ, Inst Bioelementol, Orenburg 460018, Russia
Sechenov Univ, IM Sechenov First Moscow State Med Univ, Ctr Bioelementol & Human Ecol, Moscow 119146, Russia
Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Yaroslavl 150003, RussiaAlbert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA