STABILITY OF ANTINEOPLASTON A10 IN AQUEOUS-SOLUTION

被引：3
|
作者：
OH, IJ [1 ]
LEE, JM [1 ]
LEE, YB [1 ]
SHIN, SC [1 ]
CHOI, BG [1 ]
机构：
[1] CHONNAM NATL UNIV,COLL PHARM,KWANGJU 500757,SOUTH KOREA
来源：
ARCHIVES OF PHARMACAL RESEARCH | 1995年 / 18卷 / 02期
关键词：
ANTINEOPLASTON A10; STABILITY; HYDROLYSIS; ANTICANCER AGENT;
D O I：
10.1007/BF02979137
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The analysis method and stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl-L-glutamine, one of the degradation products, can be detected by high-performance liquid chromatography. The degradation kinetics of antineoplaston A10 in aqueous solutions from pH 1 to 10 buffers were carried out at 40, 50 and 60 degrees C. Pseudo-first order kinetics were obtained throughout the entire pH ranges studied. The pH-rate profiles showed that antineoplaston A10 was very unstable in alkaline conditions and most stable at pH 4.
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页码：75 / 78
页数：4
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