STUDY OF HUMORAL IMMUNE-RESPONSE IN MAMMALS IMMUNIZED WITH PLASMODIUM-FALCIPARUM ANTIGENIC PREPARATIONS

被引：1
|
作者：
CUBAS, ABC [1 ]
CUNHA, F [1 ]
NITCHEU, IK [1 ]
ROLLAND, L [1 ]
CICERON, L [1 ]
CARVALHO, AB [1 ]
FURTADO, AF [1 ]
MONJOUR, L [1 ]
机构：
[1] C P AGGEU MAGALHAES FIOCRUZ,BR-50730 RECIFE,PE,BRAZIL
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1992年 / 87卷
关键词：
PLASMODIUM-FALCIPARUM; PROTEIN FRACTIONS; INVITRO PARASITE INHIBITION; RHOPTRY PROTEINS;
D O I：
10.1590/S0074-02761992000700072
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Six Plasmodium falciparum protein fractions, isolated under reducing conditions, were used to immunize mice, rabbits and the squirrel monkey Saimiri sciureus. Five or seven subcutaneous injections of each antigenic preparation, in conjunction with Freund's complete or incomplete adjuvants, were administered. This led to the development of specific antibodies detected by IFAT, ELISA or immunobloting which inhibited merozoite reinvasion in in vitro P. falciparum cultures. This activity seems to be associated with rhoptry proteins contained in fractions Pf F2 and Pf F4.
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收藏
页码：429 / 434
页数：6
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