MURAMYL PEPTIDE-BINDING SITES ARE LOCATED INSIDE TARGET-CELLS

被引：21

作者：

SUMAROKA, MV ^{[1
]}

LITVINOV, IS ^{[1
]}

KHAIDUKOV, SV ^{[1
]}

GOLOVINA, TN ^{[1
]}

KAMRAZ, MV ^{[1
]}

KOMALEVA, RL ^{[1
]}

ANDRONOVA, TM ^{[1
]}

MAKAROV, EA ^{[1
]}

NESMEYANOV, VA ^{[1
]}

IVANOV, VT ^{[1
]}

机构：

[1] MM SHEMYAKIN BIOORGAN CHEM INST,MOSCOW 117871,USSR

来源：

FEBS LETTERS | 1991年 / 295卷 / 1-3期

关键词：

MURAMYL PEPTIDE-BINDING SITE; MAMMALIAN CELL; FLOW CYTOMETRY;

D O I：

10.1016/0014-5793(91)81381-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using flow cytometry and fluorescence polarization analysis, specific muramyl peptide-binding sites were shown to be located inside T-lymphocytes, macrophages and neuroblastoma cells, but not inside B-cells. No binding sites were found on the cell surface. The number of binding sites for each cell type was determined. Two types of binding sites were observed for myelomonocytic WEHI-3 cells with K(d) values of 21 and 540 nM. Inhibition analysis demonstrated that for effective binding, an intact glycopeptide molecule and D-configuration of isoglutamine residue are important.

引用

页码：48 / 50

页数：3

共 50 条

[1] TARGET-CELLS FOR ADJUVANT ACTIVITY OF MURAMYL DIPEPTIDE
LOWY, I
CHEDID, L
[J]. ANNALES D IMMUNOLOGIE, 1976, C127 (02): : 107 - 108
[2] SPOT-Peptide: Template-Based Prediction of Peptide-Binding Proteins and Peptide-Binding Sites
Litfin, Thomas
Yang, Yuedong
Zhou, Yaoqi
[J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2019, 59 (02) : 924 - 930
[3] TARGET-CELLS FOR ACTIVITY OF A SYNTHETIC ADJUVANT - MURAMYL DIPEPTIDE
LOWY, I
BONA, C
CHEDID, L
[J]. CELLULAR IMMUNOLOGY, 1977, 29 (01) : 195 - 199
[4] ACCUMULATION OF A SLOWLY DISSOCIABLE PEPTIDE HORMONE BINDING COMPONENT BY ISOLATED TARGET-CELLS
DONNER, DB
MARTIN, DW
SONENBERG, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (02) : 672 - 676
[5] ACCUMULATION OF A SLOWLY DISSOCIABLE PEPTIDE HORMONE BINDING COMPONENT BY ISOLATED TARGET-CELLS
DONNER, DB
MARTIN, DW
SONENBERG, M
[J]. JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1978, : 130 - 130
[6] PepSite: prediction of peptide-binding sites from protein surfaces
Trabuco, Leonardo G.
Lise, Stefano
Petsalaki, Evangelia
Russell, Robert B.
[J]. NUCLEIC ACIDS RESEARCH, 2012, 40 (W1) : W423 - W427
[7] BINDING OF EGF TO MEMBRANES OF TARGET-CELLS
SADRNIA, MJ
LIN, MT
JOHNSON, WT
WIEHLE, R
WITTLIFF, JL
[J]. JOURNAL OF DENTAL RESEARCH, 1990, 69 : 195 - 195
[8] Peptide-Binding Nanoparticle Materials with Tailored Recognition Sites for Basic Peptides
Fa, Shixin
Zhao, Yan
[J]. CHEMISTRY OF MATERIALS, 2017, 29 (21) : 9284 - 9291
[9] EFFECT OF PULSE TREATMENT OF TARGET-CELLS WITH GUINEA-PIG LYMPHOTOXIN AND NATURE OF ITS BINDING TO TARGET-CELLS
SAWADA, J
KOBAYASHI, Y
OSAWA, T
[J]. JAPANESE JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 47 (02): : 93 - 98
[10] Targeting of peptide-binding receptors on cancer cells with peptide-drug conjugates
Worm, Dennis J.
Els-Heindl, Sylvia
Beck-Sickinger, Annette G.
[J]. PEPTIDE SCIENCE, 2020, 112 (03)

← 1 2 3 4 5 →