THE DEGRADATION OF CARBOPLATIN IN AQUEOUS-SOLUTIONS CONTAINING CHLORIDE OR OTHER SELECTED NUCLEOPHILES

The degradation kinetics of carboplatin in aqueous solution in the presence and absence of chloride ions were studied at elevated temperatures (43-70-degrees-C) at pH 7.0 and at various pH values at 70-degrees-C. Reaction rates were then extrapolated to temperatures of interest (infusion storage temperature, 'in-use' infusion temperature and body temperature) from Arrhenius plots. Additionally, the effects of pH and added chloride, thiosulphate, thiocyanate, azide and iodide on the rate of degradation of carboplatin were determined in an attempt to obtain a greater insight into the mechanism of nucleophilic substitution of carboplatin.