EFFECT OF MATERNAL CAFFEINE AND RETINOIC ACID INTAKE ON LIVER DURING PRE- AND POSTNATAL DEVELOPMENT OF MICE, MUS MUSCULUS

The present study was conducted to evaluate the effect of caffeine and retinoic acid as the active metabolite form of vitamin A on the liver at pre-and postnatal periods of development. In either the pre- or the postnatal period of study, caffeine was able to perturb carbohydrates, increase calcium and decrease iron those accompanied with down regulated expression of TGF beta 2 in hepatic tissue as compared to control. Treatment with retinoic acid at both doses in the present study either separate or combined with caffeine upregulate calcium against suppression of iron. Moreover, TGF beta 2 show biphasic that severely down regulated during gestation and extended to express intranuclear at postnatal in liver tissue. Decreased iron overload of liver with concomitant down regulation of TGF beta 2 expression represent the most important points of this study that protect the liver of young age from oxidative damage and suppress the gene-dependent extracellular matrix deposition. These data may contribute to the therapeutic uses of these substances in preventing the progression of liver damage in hepatitis diseases.