ROLE OF ADHESION MOLECULES IN THE PATHOGENESIS OF RHEUMATOID-ARTHRITIS

被引：0
|
作者：
LIAO, HX
HAYNES, BF
机构：
[1] DUKE UNIV, SCH MED, DEPT MED, DURHAM, NC 27710 USA
[2] LEUKEMIA SOC AMER, DURHAM, NC USA
[3] DUKE UNIV, MED CTR, DURHAM, NC USA
[4] DUKE UNIV, ARTHRIT CTR, DURHAM, NC USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1995年 / 21卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pathogenesis of rheumatoid arthritis centers on as yet unknown initiating events in the synovium that result in synovial vessel proliferation, and upregulation of endothelial cell ligands for leukocyte adhesion molecules. Ligation of adhesion molecules on synovial microenvironment cells and immune cells probably regulates synovial and immune cell inflammatory cytokine production. interruption of adhesion molecule function and interruption of inflammatory cytokine production are promising new sites of therapeutic inhibition of synovial inflammation.
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页码：715 / 740
页数：26
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