MAPPING OF THE INTERLEUKIN-5 RECEPTOR GENE TO HUMAN CHROMOSOME-3 P25-P26 AND TO MOUSE CHROMOSOME-6 CLOSE TO THE RAF-1 LOCUS WITH POLYMORPHIC TANDEM REPEAT SEQUENCES

被引：7

作者：

JACOB, CO

MYKYTYN, K

VARCONY, T

DRABKIN, HA

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,CANC BIOL PROGRAM,STANFORD,CA 94305

[2] UNIV COLORADO,HLTH SCI CTR,DIV MED ONCOL,DENVER,CO 80262

来源：

MAMMALIAN GENOME | 1993年 / 4卷 / 08期

关键词：

D O I：

10.1007/BF00296817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.

引用

页码：435 / 439

页数：5

共 8 条

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