THE ACTIVITY OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 (PAI-1) OF HUMAN PLATELET

被引：35

作者：

BOOTH, NA ^{[1
]}

CROLL, A ^{[1
]}

BENNETT, B ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT MED & THERAPEUT,ABERDEEN AB9 1AS,SCOTLAND

来源：

FIBRINOLYSIS | 1990年 / 4卷

关键词：

PAI-1; Plasminogen activator inhibitor; Platelets;

D O I：

10.1016/0268-9499(90)90391-V

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have previously shown that platelets account for 93% of circulating PAI-1 antigen but for only half the PAI activity, suggesting that platelet PAI-1 is less active than plasma PAI-1. Here we show, both by an assay for the PAI-1 that is capable of forming a complex with t-PA and by a chromogenic assay for PAI activity, that human platelet PAI-1 is 3.5 ± 1.1% active. Human PAI-1, purified either from platelets or endothelial cells, was reactivated by 4M guanidine to a final specific activity of about 300,000 U/mg PAI-1. © 1990.

引用

页码：138 / 140

页数：3

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