INTRAPLEURAL PALLIATIVE TREATMENT OF MALIGNANT PLEURAL EFFUSIONS WITH MITOXANTRONE VERSUS PLACEBO (PLEURAL TUBE ALONE)

被引：50

作者：

GROTH, G ^{[1
]}

GATZEMEIER, U ^{[1
]}

HAUSSINGEN, K ^{[1
]}

HECKMAYR, M ^{[1
]}

MAGNUSSEN, H ^{[1
]}

NEUHAUSS, R ^{[1
]}

PAVEL, JV ^{[1
]}

机构：

[1] HOSP GAUTING,DEPT PNEUMOL,MUNICH,GERMANY

来源：

ANNALS OF ONCOLOGY | 1991年 / 2卷 / 03期

关键词：

MALIGNANT PLEURAL EFFUSION; INTRAPLEURAL TREATMENT; MITOXANTRONE; PLACEBO;

D O I：

10.1093/oxfordjournals.annonc.a057908

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

From 11/87 until 7/90 103 patients entered a prospective randomized trial on the treatment of malignant pleural effusions (MPE) with intrapleural mitoxantrone versus placebo (pleural tube alone with instillation of isotonic NaCl). Our data suggest no statistically significant difference between the two arms with respect to response and response duration. There is no influence on survival time. The toxicity is moderate, with only fever occurring more often in the mitoxantrone arm. We recommend performance of pleurodesis in patients with MPE first by sufficient drainage with a tube of 16-20 char. Only in instances of failure it is necessary to add sclerosing agents such as tetracycline, etc.

引用

页码：213 / 215

页数：3

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