THE EFFECT OF HALOTHANE ON CULTURED FIBROBLASTS AND NEUROBLASTOMA-CELLS

被引：3
|
作者：
UEMURA, E [1 ]
LEVIN, ED [1 ]
机构：
[1] DUKE UNIV,DEPT PSYCHIAT,DURHAM,NC 27710
来源：
NEUROSCIENCE LETTERS | 1992年 / 145卷 / 01期
关键词：
HALOTHANE; TISSUE CULTURE; ACTIN; NEURITE; FIBROBLAST; NEUROBLASTOMA CELL;
D O I：
10.1016/0304-3940(92)90196-E
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Halothane exposure over the cultured cells (100 and 1,000 ppm) caused a disruption of the pattern of actin distribution in both fibroblasts and neuroblastoma cells. Neuroblastoma cells exposed to halothane also lost microspikes; however, neurite elongation was not affected by halothane. The present study suggests that halothane induces the functional disruption of actin, resulting in an interference of normal neural development in vivo.
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收藏
页码：33 / 36
页数：4
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