AUTOIMMUNE ADDISONS-DISEASE - EVIDENCE FOR A ROLE OF STEROID 21-HYDROXYLASE AUTOANTIBODIES IN ADRENAL INSUFFICIENCY

被引：42
|
作者：
FURMANIAK, J
KOMINAMI, S
ASAWA, T
WEDLOCK, N
COLLS, J
SMITH, BR
机构：
[1] HIROSHIMA UNIV, FAC INTEGRATED ARTS & SCI, HIROSHIMA 724, JAPAN
[2] RSR LTD, CARDIFF CF2 7HE, S GLAM, WALES
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1994年 / 79卷 / 05期
关键词：
D O I：
10.1210/jc.79.5.1517
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoantibodies to steroid 21-hydroxylase (21-OH) are characteristic of adult onset Addison's disease and we have investigated the effects of these autoantibodies on recombinant human 21-OH enzyme activity. Antibody preparations from 11/11 Addison sera inhibited the ability of 21-OH to convert progesterone to deoxycorticosterone with 8 IgGs showing almost complete inhibition, 2 partial inhibition and 1 weak inhibition. Control IgGs from patients with autoimmune thyroid disease and normal blood donors had little or no effect on 21-OH activity. Our results suggest that 21-OH autoantibodies have the potential to contribute to adrenal failure in Addison's disease by inhibiting the 21-OH enzyme.
引用
收藏
页码：1517 / 1521
页数：5
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