DORSAL STRIATAL DOPAMINE D-1 AND D-2 RECEPTORS ARE INVOLVED IN THE CARBACHOL-MEDIATED POTENTIATION OF APOMORPHINE-INDUCED JAW MOVEMENTS

The role of dorsal striatal mechanisms in the regulation of apomorphine-induced jaw movements was studied. Jaw movements induced by apomorphine (0.2 mg/kg i.v.) were potentiated by carbachol (0.1 mu g/0.2 mu l) injected into the dorsal part of the striatum 10 min before apomorphine. The potentiation was prevented by l-sulpiride (25 ng), nemonapride (0.1 mu g) or SCH23390 (0.1 mu g), but not muscimol (50 ng). Injection of these drugs alone into the dorsal striatum failed to alter the effects of apomorphine. These results suggest that dopamine D-1 and D-2 receptors in the dorsal striatum participate in the carbachol-mediated potentiation of apomorphine-induced jaw movements.