RESPONSIVE POLYMER SYSTEMS FOR CONTROLLED DELIVERY OF THERAPEUTICS

被引：55
|
作者：
KOST, J [1 ]
LANGER, R [1 ]
机构：
[1] MIT, DEPT CHEM ENGN, CAMBRIDGE, MA 02139 USA
来源：
TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 04期
关键词：
D O I：
10.1016/0167-7799(92)90194-Z
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The ideal drug-delivery system should provide therapeutics in response to physiological requirements, having the capacity to 'sense' changes and alter the drug-release process accordingly. Such responsive controlled delivery systems are still at an experimental stage. This review focuses on two basic approaches: (1) externally regulated systems (utilizing triggers such as magnetism, ultrasound, temperature and electricity), and (2) self-regulated systems (utilizing pH-sensitive polymers, enzyme-substrate reactions, competitive binding, and antibody interactions).
引用
收藏
页码：127 / 131
页数：5
相关论文
共 50 条
  • [1] Responsive polymer systems for controlled delivery of therapeutics
    Kost, J.
    Langer, R.
    Trends in Biotechnology, 1992, 10 (04): : 127 - 131
  • [2] Intelligent, responsive and theranostic hydrogel systems for controlled delivery of therapeutics
    Marek, Steve R.
    Gran, Martin L.
    Peppas, Nicholas A.
    Caldorera-Moore, Mary
    RSC Smart Materials, 2015, 2015-January (14): : 10 - 43
  • [3] Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
    Ekkelenkamp, Antonie E.
    Elzes, M. Rachel
    Engbersen, Johan F. J.
    Paulusse, Jos M. J.
    JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (02) : 210 - 235
  • [4] Stimulus-responsive viral vectors for controlled delivery of therapeutics
    Brun, Mitchell J.
    Gomez, Eric J.
    Suh, Junghae
    JOURNAL OF CONTROLLED RELEASE, 2017, 267 : 80 - 89
  • [5] Importance of controlled delivery systems for regenerative therapeutics
    Khang, Gilson
    Tripathy, Nirmalya
    THERAPEUTIC DELIVERY, 2014, 5 (10) : 1053 - 1055
  • [6] Polymer mediated light responsive therapeutics delivery system to treat cancer
    Kapoor, Devesh
    Maheshwari, Neha
    Bag, Anindita
    Sharma, Mukesh C.
    Prajapati, Bhupendra
    Maheshwari, Rahul
    EUROPEAN POLYMER JOURNAL, 2024, 210
  • [7] Enzymatically controlled responsive drug delivery systems
    Goldbart, R
    Traitel, T
    Lapidot, SA
    Kost, J
    POLYMERS FOR ADVANCED TECHNOLOGIES, 2002, 13 (10-12) : 1006 - 1018
  • [8] Novel delivery systems for controlled release of bacterial therapeutics
    Zaragoza, Nadia
    Anderson, Grace I.
    Allison-Logan, Stephanie
    Monir, Kirmina
    Furst, Ariel L.
    TRENDS IN BIOTECHNOLOGY, 2024, 42 (07) : 929 - 937
  • [9] Stimuli-responsive boronic acid block copolymers for the controlled delivery of therapeutics
    Cambre, Jennifer N.
    Roy, Debashish
    Sumerlin, Brent S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [10] Polymer-Based Drug Delivery Systems for Cancer Therapeutics
    Ding, Ling
    Agrawal, Prachi
    Singh, Sandeep K.
    Chhonker, Yashpal S.
    Sun, Jingjing
    Murry, Daryl J.
    POLYMERS, 2024, 16 (06)
12345