STIMULATION OF PROTEIN-KINASE-C (PKC) ACTIVITY IN RESTING SWISS 3T3 CELLS BY PROSTAGLANDIN-F2-ALPHA

被引：9

作者：

GOIN, M ^{[1
]}

DEASUA, LJ ^{[1
]}

机构：

[1] INST INVEST INGN GENET & BIOL MOLEC,OBLIGADO 2490,RA-1428 BUENOS AIRES,ARGENTINA

来源：

FEBS LETTERS | 1992年 / 297卷 / 1-2期

关键词：

SWISS; 3T3-CELL; PROSTAGLANDIN-F2-ALPHA; PROTEIN KINASE-C; 80; K-PHOSPHORYLATION; DNA SYNTHESIS;

D O I：

10.1016/0014-5793(92)80354-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin F2(alpha) (PGF2(alpha)), a mitogen for resting Swiss 3T3 cells, rapidly stimulates phosphorylation of an 80 kDa protein (80 K). 1-Oleoyl-2-acetylglycerol (OAG) and 12-O-tetradecanoyl phorbol-13-acetate (TPA) both protein kinase C (PKC) activators, also elicit 80 K phosphorylation. In contrast PGE1, PGE2 or PGF2(beta), which are non-mitogenic in these cells, had little or no action on this event. However PGE1 and PGE2 potentiate the PGF2(alpha) proliferative effect but do not enhance its action on 80 K phosphorylation. These results suggest that PGF2(alpha) mitogenic induction involves PKC signalling pathway activation while its enhancement by PGE1 or PGE2 occurs through a different mechanism(s).

引用

页码：175 / 178

页数：4

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