EVALUATION OF KETOROLAC, ASPIRIN, AND AN ACETAMINOPHEN-CODEINE COMBINATION IN POSTOPERATIVE ORAL-SURGERY PAIN

被引:0
|
作者
FORBES, JA
BUTTERWORTH, GA
BURCHFIELD, WH
BEAVER, WT
机构
[1] JOHNS HOPKINS UNIV, SCH MED, DEPT PSYCHIAT, BALTIMORE, MD 21205 USA
[2] GEORGETOWN UNIV, SCH MED, DEPT PHARMACOL, WASHINGTON, DC 20057 USA
[3] GEORGETOWN UNIV, SCH MED, DEPT ANESTHESIA, WASHINGTON, DC 20057 USA
来源
PHARMACOTHERAPY | 1990年 / 10卷 / 06期
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中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
One-hundred twenty-eight outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive oral doses of ketorolac tromethamine 10 mg, aspirin 650 mg, a combination of acetaminophen 600 mg plus codeine 60 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. All active medications were significantly superior to placebo. The acetaminophen-codeine combination was significantly superior to aspirin for peak analgesia. Ketorolac was significantly superior to aspirin for every measure of total and peak analgesia, and significantly superior to acetaminophen-codeine for measures of total effect. The analgesic effect of ketorolac was significant by hour 1 and persisted for 6 hours. Repeat-dose data also suggested that ketorolac 10 mg was superior to aspirin 650 mg and acetaminophen-codeine on the day of surgery. Differences among the active medications were trivial for the postoperative days 1-6 analyses. The frequency of adverse effects was over 4 times greater for acetaminophen-codeine than for ketorolac or aspirin.
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页码:S77 / S93
页数:17
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