Clinical Use of Proteasome Inhibitors in the Treatment of Multiple Myeloma

被引：69
|
作者：
Merin, Noah M. [1 ]
Kelly, Kevin R. [1 ]
机构：
[1] Univ Southern Calif, Keck Sch Med, Jane Anne Nohl Div Hematol, Internal Med, Los Angeles, CA 90033 USA
来源：
PHARMACEUTICALS | 2015年 / 8卷 / 01期
关键词：
multiple myeloma; proteasome inhibitors; toxicity;
D O I：
10.3390/ph8010001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Multiple myeloma (MM) is an incurable hematological malignancy characterized by the clonal proliferation of neoplastic plasma cells. The use of proteasome inhibitors in the treatment of MM has led to significant improvements in outcomes. This article reviews data on the use of the two approved proteasome inhibitors (bortezomib and carlfilzomib), as well as newer agents under development. Emphasis is placed on the clinical use of proteasome inhibitors, including management of side effects and combination with other agents.
引用
收藏
页码：1 / 20
页数：20
相关论文
共 50 条
  • [1] Use of proteasome inhibitors in the treatment of patients with multiple myeloma
    Rukavitsyn, O. A.
    [J]. TERAPEVTICHESKII ARKHIV, 2006, 78 (10): : 40 - 44
  • [2] PROTEASOME INHIBITORS FOR USE IN MULTIPLE MYELOMA
    Jain, S.
    Satija, N.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (02): : 320 - 329
  • [3] Proteasome inhibitors in the treatment of multiple myeloma
    McBride, Ali
    Ryan, Patricia Y.
    [J]. EXPERT REVIEW OF ANTICANCER THERAPY, 2013, 13 (03) : 339 - 358
  • [4] Proteasome inhibitors in the treatment of multiple myeloma
    J J Shah
    R Z Orlowski
    [J]. Leukemia, 2009, 23 : 1964 - 1979
  • [5] Proteasome Inhibitors for the Treatment of Multiple Myeloma
    Ito, Shigeki
    [J]. CANCERS, 2020, 12 (02)
  • [6] Proteasome inhibitors for the treatment of multiple myeloma
    Scalzulli, Emilia
    Grammatico, Sara
    Vozella, Federico
    Petrucci, Maria Teresa
    [J]. EXPERT OPINION ON PHARMACOTHERAPY, 2018, 19 (04) : 375 - 386
  • [7] Proteasome inhibitors in the treatment of multiple myeloma
    Shah, J. J.
    Orlowski, R. Z.
    [J]. LEUKEMIA, 2009, 23 (11) : 1964 - 1979
  • [8] Role of proteasome inhibitors as treatment of multiple myeloma
    Pasquier, Florence
    Moreau, Anne-Sophie
    Tricot, Sabine
    Wemeau, Mathieu
    Facon, Thierry
    Leleu, Xavier
    [J]. HEMATOLOGIE, 2006, 12 (01): : 67 - 76
  • [9] New proteasome inhibitors in the treatment of multiple myeloma
    de Moraes Hungria, Vania Tietsche
    Crusoe, Edvan de Queiroz
    Bittencourt, Rosane Isabel
    Maiolino, Angelo
    Pessoa Magalhaes, Roberto Jose
    Sobrinho, Jairo do Nascimento
    Pinto, Jorge Vaz
    Fortes, Ricardo Coutinho
    Moreira, Eloisa de Sa
    Tanaka, Paula Yurie
    [J]. HEMATOLOGY TRANSFUSION AND CELL THERAPY, 2019, 41 (01) : 76 - 83
  • [10] Safety of proteasome inhibitors for treatment of multiple myeloma
    Schlafer, Danielle
    Shah, Katherine S.
    Panjic, Elyse Hall
    Lonial, Sagar
    [J]. EXPERT OPINION ON DRUG SAFETY, 2017, 16 (02) : 167 - 183
12345