GLYCINE ENHANCES [H-3] NORADRENALINE RELEASE FROM SLICES OF RAT HIPPOCAMPUS

被引：4
|
作者：
RAITERI, M
FEDELE, E
FONTANA, G
PITTALUGA, A
机构：
[1] Istituto di Farmacologia e Farmacognosia, Università degli Studi di Genova, Genova
来源：
NEUROSCIENCE LETTERS | 1990年 / 116卷 / 03期
关键词：
Glycine; Rat hippocampus; Strychnine-sensitive receptor; [!sup]3[!/sup]H]Noradrenaline release;
D O I：
10.1016/0304-3940(90)90100-N
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of glycine on the release of [3H]noradrenaline ([3H]NA) have been investigated using rat hippocampus slices previously labeled with the radioactive catecholamine. Glycine (30-1000 μM) produced a potent and concentration-dependent increase of the release of [3H]NA evoked by 12 mM KCl. The effect of 1000 μM glycine was totally antagonized by 3 μM strychnine suggesting that, in rat hippocampus, glycine may regulate the release of NA by activating a receptor of the strychnine-sensitive subtype. © 1990.
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页码：352 / 356
页数：5
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