GLYCINE ENHANCES [H-3] NORADRENALINE RELEASE FROM SLICES OF RAT HIPPOCAMPUS

被引:4
|
作者
RAITERI, M
FEDELE, E
FONTANA, G
PITTALUGA, A
机构
[1] Istituto di Farmacologia e Farmacognosia, Università degli Studi di Genova, Genova
关键词
Glycine; Rat hippocampus; Strychnine-sensitive receptor; [!sup]3[!/sup]H]Noradrenaline release;
D O I
10.1016/0304-3940(90)90100-N
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of glycine on the release of [3H]noradrenaline ([3H]NA) have been investigated using rat hippocampus slices previously labeled with the radioactive catecholamine. Glycine (30-1000 μM) produced a potent and concentration-dependent increase of the release of [3H]NA evoked by 12 mM KCl. The effect of 1000 μM glycine was totally antagonized by 3 μM strychnine suggesting that, in rat hippocampus, glycine may regulate the release of NA by activating a receptor of the strychnine-sensitive subtype. © 1990.
引用
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页码:352 / 356
页数:5
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