THE EFFECT OF TRH ON ETHANOL-INDUCED SEDATION IN ALCOHOL-PREFERRING AND ALCOHOL-NONPREFERRING RATS

被引：8
|
作者：
MORZORATI, S
KUBEK, MJ
机构：
[1] INDIANA UNIV, SCH MED, REGENSTRIEF INST, DEPT ANAT, INDIANAPOLIS, IN 46202 USA
[2] INDIANA UNIV, SCH MED, PROGRAM MED NEUROBIOL, INDIANAPOLIS, IN 46202 USA
来源：
NEUROPEPTIDES | 1993年 / 25卷 / 05期
关键词：
D O I：
10.1016/0143-4179(93)90045-C
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
TRH antagonism of ethanol sedation was evaluated in selectively-bred alcohol-preferring (P) and -nonpreferring (NP) rats. Intracerebroventricular (i.c.v.) infusions of TRH significantly reduced sleep time in the NP rats. In the P rats, TRH tended to reduce sleep, but this reduction was not significant. TRH had no significant effect on peripheral blood alcohol concentrations. The present results show that NP rats are more sensitive to the analeptic effect of TRH compared to P rats. These data support and extend those of others who have demonstrated a TRH antagonism on drug-induced sedation. Differential sensitivity to TRH may reflect differences in TRH receptor activity and/or TRH metabolism. Sensitivity to TRH analepsis may be associated with sensitivity to ethanol.
引用
收藏
页码：283 / 287
页数：5
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