Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system

This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing (d(001)) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.