Quantitative trait loci mapping

被引：0
|
作者：
Grisel, JE [1 ]
Crabbe, JC [1 ]
机构：
[1] OREGON HLTH SCI UNIV,SCH MED,PORTLAND,DORSET,ENGLAND
来源：
ALCOHOL HEALTH & RESEARCH WORLD | 1995年 / 19卷 / 03期
关键词：
AOD use behavior; animal strains; hereditary factors; genetic mapping; genetic markers;
D O I：
暂无
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Researchers interested in the physical locations of genes that influence a person's alcohol-related behaviors can use a method known as quantitative trait loci (QTL) mapping to identify the approximate locations of genes in the genome. QTL mapping can use recombinant inbred mouse strains, which are sets of inbred strains derived from cross-breeding the offspring of two genetically distinct parent strains. The inbred strains exhibit different patterns of the parent strains' genes. QTL mapping involves comparing alcohol-related behaviors in these strains and identifying patterns of known genetic markers shared by strains with the same behaviors. The markers allow the identification of probable locations of genes that influence alcohol-related behaviors. These locations can then be verified using other tests, and specific genes can be sought there.
引用
收藏
页码：220 / 227
页数：8
相关论文
共 50 条
  • [1] Mapping epistatic quantitative trait loci
    Cecelia Laurie
    Shengchu Wang
    Luciana Aparecida Carlini-Garcia
    Zhao-Bang Zeng
    [J]. BMC Genetics, 15
  • [2] PRECISION MAPPING OF QUANTITATIVE TRAIT LOCI
    ZENG, ZB
    [J]. GENETICS, 1994, 136 (04) : 1457 - 1468
  • [3] Mapping epistatic quantitative trait loci
    Laurie, Cecelia
    Wang, Shengchu
    Carlini-Garcia, Luciana Aparecida
    Zeng, Zhao-Bang
    [J]. BMC GENETICS, 2014, 15
  • [4] In silico mapping of quantitative trait loci in maize
    Parisseaux B.
    Bernardo R.
    [J]. Theoretical and Applied Genetics, 2004, 109 (3) : 508 - 514
  • [5] INTERVAL MAPPING OF MULTIPLE QUANTITATIVE TRAIT LOCI
    JANSEN, RC
    [J]. GENETICS, 1993, 135 (01) : 205 - 211
  • [6] Score Statistics for Mapping Quantitative Trait Loci
    Chang, Myron N.
    Wu, Rongling
    Wu, Samuel S.
    Casella, George
    [J]. STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 2009, 8 (01)
  • [7] Bayesian LASSO for quantitative trait loci mapping
    Yi, Nengjun
    Xu, Shizhong
    [J]. GENETICS, 2008, 179 (02) : 1045 - 1055
  • [8] Hybrid bootstrap for mapping quantitative trait loci
    Sun, Hokeun
    Keener, Robert W.
    Kim, Dong-Yun
    [J]. STATISTICS & PROBABILITY LETTERS, 2010, 80 (15-16) : 1253 - 1259
  • [9] In silico mapping of quantitative trait loci in maize
    Parisseaux, B
    Bernardo, R
    [J]. THEORETICAL AND APPLIED GENETICS, 2004, 109 (03) : 508 - 514
  • [10] Selection bias in quantitative trait loci mapping
    Lee, C
    [J]. JOURNAL OF HEREDITY, 2005, 96 (04) : 363 - 367
12345