VARIABILITY IN CLINICAL-PHARMACOLOGY OF DRUGS IN CHILDREN

被引：7
|
作者：
NAHATA, MC
机构：
[1] OHIO STATE UNIV,COLL MED,COLUMBUS,OH 43210
[2] CHILDRENS HOSP,WEXNER INST PEDIAT RES,COLUMBUS,OH 43205
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1992年 / 17卷 / 06期
关键词：
D O I：
10.1111/j.1365-2710.1992.tb01319.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Numerous factors can lead to variability in pharmacokinetics, pharmacodynamics, efficacy, and toxicity of drugs in infants and children. These may include age, race or genetic status, organ function, underlying disease(s), drug formulation, concomitant drugs, and compliance with therapy. Further research is needed to clarify the mechanisms for variability in drug response to achieve optimal use of drugs in paediatric patients.
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页码：365 / 368
页数：4
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