Individual differences in animal models: an approach to study neurobiological factors related to depression

被引:0
|
作者
Cordero, Andrey Sequeira [1 ]
Trias, Jaime Fornaguera [2 ]
机构
[1] Univ Costa Rica, CIN, Inst Invest Salud INISA, San Pedro 115012060, San Jose, Costa Rica
[2] Univ Costa Rica, CIN, Inst Invest Salud INISA, Escuela Med, San Pedro 115012060, San Jose, Costa Rica
来源
ACTUALIDADES EN PSICOLOGIA | 2014年 / 28卷 / 117期
关键词
Individual differences; forced swimming test; behavior; gene expression; brain;
D O I
10.15517/ap.v28i117.14115
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression- related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain- derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line.
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页码:53 / 65
页数:13
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