IMPAIRED NITRIC-OXIDE RELEASE BY GLOMERULI FROM DIABETIC RATS

被引：42
|
作者：
CRAVEN, PA
STUDER, RK
DERUBERTIS, FR
机构：
[1] VET AFFAIRS MED CTR,DEPT MED,PITTSBURGH,PA
[2] UNIV PITTSBURGH,PITTSBURGH,PA
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 1995年 / 44卷 / 06期
关键词：
D O I：
10.1016/0026-0495(95)90178-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Basal nitric oxide (NO) production and NO responses to carbamylcholine (CCh) and the Ca2+ ionophore A23187 were measured with a NO electrode in glomeruli isolated from 2 to 3-month-diabetic versus age-matched control rats. In the presence of CCh or A23187, NO production was markedly reduced in glomeruli from diabetic versus control rats. Spontaneous generation of NO by s-nitrosopenicillamine (SNAP) was also reduced in the presence of glomeruli from diabetic rats as compared with values either in control glomeruli or in buffer alone. The results demonstrate an impairment of NO generation and/or stability in glomeruli from 2 to 3-month-diabetic rats, which correlates with the previously observed suppression of NO-dependent glomerular cyclic guanosine 3',5'-monophosphate (cGMP) induced by diabetes. Copyright (C) 1995 by W.B. Saunders Company
引用
收藏
页码：695 / 698
页数：4
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