ENZYMATIC-SYNTHESIS OF OPTICALLY-ACTIVE (S)-(+)-2-HYDROXYMETHYL-3,4-DIHYDRO-2H-PYRAN AND (S)-(+)-2-ACETOXYMETHYL-3,4-DIHYDRO-2H-PYRAN

被引：13
|
作者：
KANG, SK
JEON, JH
YAMAGUCHI, T
HONG, RK
KO, BS
机构：
[1] Department of Chemistry, Sung Kyun Kwan University, Suwon, 440-746, Natural Science Campus
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 01期
关键词：
D O I：
10.1016/0957-4166(94)00361-E
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Porcine pancreas lipase(PPL)-catalyzed acetylation of(+/-)-2-hydroxymethyl-3,4-dihydro-2H-pyran with vinyl acetate in organic solvent afforded (S)-(+)-2-acetoxymethyl-3,4-dihydro-2H-pyran. Alternatively, (+/-)-2-acetoxymethyl-3,4-dihydro-2H-pyran was resolved via hydrolysis catalyzed by PPL in acetone-phosphate buffer system to afford (S)-(+)-2-hydroxymethyl-3,4-dihydro-2H-pyran with high enantiomeric purity.
引用
收藏
页码：97 / 100
页数：4
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