Genetic susceptibility for addiction: Searching of risk loci for the widespread drugs of abuse

被引：0
|
作者：
Buscemi, Loredana [1 ]
Onori, Nicoletta [1 ]
Turchi, Chiara [1 ]
Solito, Giovanni [1 ]
Tagliabracci, Adriano [1 ]
机构：
[1] Univ Politecn Marche, Inst Legal Med, Dipartimento Neurosci, I-60126 Ancona, Italy
来源：
FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES | 2009年 / 2卷 / 01期
关键词：
Alcoholism; 3'-GABRA2; SNPs; Case-control study;
D O I：
10.1016/j.fsigss.2009.08.065
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Addiction to drugs of abuse is the major health and social issue, for its morbidity and mortality, individual and society cost, violence and legal problems involvement. The susceptibility to addiction has a complex genetic basis characterized by phenotypic and genetic heterogeneity as well as polygenicity. Both linkage mapping and association mapping have identified susceptibility loci for addiction-related phenotypes. In this study we limit our focus to gamma-amino butyric acid A receptor alpha 2 (GABRA2), one of the candidate gene in addiction, in order to investigate the genetic susceptibility of alcoholism. 10 SNPs across the 30-GABRA2 were analyzed in an Italian sample of 149 cases and 278 healthy controls. No SNP and haplotype association of 30-GABRA2 with AUDs was found, in contrast to previous reports in other Caucasian populations. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：487 / 488
页数：2
相关论文
共 50 条
  • [1] Abuse of prescription drugs and the risk of addiction
    Compton, Wilson A.
    Volkow, Nora D.
    DRUG AND ALCOHOL DEPENDENCE, 2006, 83 : S4 - S7
  • [2] Dopamine and addiction to drugs of abuse
    Tassin, JP
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2002, 186 (02): : 295 - 305
  • [3] Neurobiology of addiction to drugs of abuse
    Gil-Verona, JA
    Pastor, JF
    de Paz, F
    Barbosa, M
    Macías-Fernández, JA
    Maniega, MA
    Rami-González, L
    Cañizares-Alejos, S
    REVISTA DE NEUROLOGIA, 2003, 36 (04) : 361 - 365
  • [4] Genetic susceptibility to addiction
    Nestler, EJ
    BIOLOGICAL PSYCHIATRY, 1999, 45 (08) : 48S - 48S
  • [5] ANXIOLYTIC DRUGS - DEPENDENCE, ADDICTION AND ABUSE
    LADER, M
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 1994, 4 (02) : 85 - 91
  • [6] Adjuvants for vaccines to drugs of abuse and addiction
    Alving, Carl R.
    Matyas, Gary R.
    Torres, Oscar
    Jalah, Rashmi
    Beck, Zoltan
    VACCINE, 2014, 32 (42) : 5382 - 5389
  • [7] Genetic Susceptibility Loci, Pesticide Exposure and Prostate Cancer Risk
    Koutros, Stella
    Berndt, Sonja I.
    Barry, Kathryn Hughes
    Andreotti, Gabriella
    Hoppin, Jane A.
    Sandler, Dale P.
    Yeager, Meredith
    Burdett, Laurie A.
    Yuenger, Jeffrey
    Alavanja, Michael C. R.
    Freeman, Laura E. Beane
    PLOS ONE, 2013, 8 (04):
  • [8] DRUGS OF ABUSE AND VIRUS SUSCEPTIBILITY
    FRIEDMAN, H
    KLEIN, T
    SPECTER, S
    PROSS, S
    NEWTON, C
    BLANCHARD, DK
    WIDEN, R
    ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY, 1988, 44 : 125 - 137
  • [9] THE NEGATIVE SIDE OF EMOTIONS: ADDICTION TO DRUGS OF ABUSE
    Contreras, M.
    Ceric, F.
    Torrealba, F.
    REVISTA DE NEUROLOGIA, 2008, 47 (09) : 471 - 476
  • [10] Drugs of Abuse: Epigenetic Mechanisms in Toxicity and Addiction
    Kovatsi, L.
    Fragou, D.
    Samanidou, V.
    Njau, S.
    Kouidou, S.
    CURRENT MEDICINAL CHEMISTRY, 2011, 18 (12) : 1765 - 1774
12345